deniskatz

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For more than half a century, major depressive disorder (MDD) has largely been interpreted through a neurochemical lens. The prevailing framework focused on deficiencies or imbalances in serotonin, norepinephrine, and dopamine, leading to generations of therapies designed to modulate synaptic signaling. While these approaches improved outcomes for many patients, they have not fundamentally solved the problem of durable remission. A significant proportion of patients remain treatment resistant, and relapse rates continue to challenge long-term disease management.
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deniskatz agregó una foto Other
2026-05-23 06:08:09 -

Real-World Evidence in Orthopedic Implant Development From Post-Market Surveillance to Continuous Performance Intelligence
Executive Summary Orthopedic implant manufacturers are operating in a fundamentally different evidence environment than they were a decade ago. Regulatory agencies, payers, hospital systems, and clinicians no longer evaluate implants solely on the basis of controlled clinical trial outcomes. Increasingly, they expect manufacturers to demonstrate how devices perform across diverse patient...

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deniskatz updated the profile picture
2026-05-22 07:16:31 -

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